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英语翻译The transport of hydrophilic macromolecules via the para

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英语翻译
The transport of hydrophilic macromolecules via the paracellular pathway is,however,
severely restricted by the presence of tight junctions which are located at the luminal aspect of adjacent epithelial cells.[ 5 ]Tight junctions consist of a complex of trans-membrane (e.g.,occuludin,claudin,JAM) and cytoplasmic (e.g.,ZO-1,ZO-2,ZO-3,cingulin) proteins and are dynamically regulated by complex physiological mechanisms.[ 6 ] ZO-1 proteins are thought to be a linkage molecule between occludin and actin cytoskeleton and play important roles in the rearrangement of cell–cell contacts.
英语翻译The transport of hydrophilic macromolecules via the para
然而,通过旁细胞途径的亲水性大分子的输送,被位于相邻的上皮细胞的细胞腔的紧密联结所严格限制.[5] 紧密联结由一个复杂的贯穿膜(例如,连接蛋白,封闭蛋白,联结黏附分子)和细胞质蛋白质组成(例如,ZO- 1,ZO- 2,ZO- 3,扣带蛋白)同时被一种复杂的生理机制动态地控制着.[6] ZO -1蛋白被认为是一个闭锁蛋白和肌动蛋白细胞骨架之间的联结分子,并在细胞与细胞联系的重新排列中发挥重要作用.
JAM:Junction Adhesion Molecule 联结黏附分子
cingulin 扣带蛋白
occludin 闭锁蛋白