英语翻译In conventional alphabeta T cells,the Tec family tyrosin
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英语翻译
In conventional alphabeta T cells,the Tec family tyrosine kinase Itk is required for signaling downstream of the T cell receptor (TCR).Itk also regulates alphabeta T cell development,lineage commitment,and effector function.A well established feature of Itk(-/-) mice is their inability to generate T helper type 2 (Th2) responses that produce IL-4,IL-5,and IL-13; yet these mice have spontaneously elevated levels of serum IgE and increased numbers of germinal center B cells.Here we show that the source of this phenotype is gammadelta T cells,as normal IgE levels are observed in Itk(-/-)Tcrd(-/-) mice
In conventional alphabeta T cells,the Tec family tyrosine kinase Itk is required for signaling downstream of the T cell receptor (TCR).Itk also regulates alphabeta T cell development,lineage commitment,and effector function.A well established feature of Itk(-/-) mice is their inability to generate T helper type 2 (Th2) responses that produce IL-4,IL-5,and IL-13; yet these mice have spontaneously elevated levels of serum IgE and increased numbers of germinal center B cells.Here we show that the source of this phenotype is gammadelta T cells,as normal IgE levels are observed in Itk(-/-)Tcrd(-/-) mice
在传统的T细胞,alphabeta Tec家庭需要酪氨酸激酶Itk信号下游的T细胞受体(细胞).Itk更能调整alphabeta T细胞的发展,天堂承诺,而且效应功能.于Itk特征(/ -)小鼠产生根本不助手二型(产生)的反应IL-4核,IL-5,IL-13;然而...
英语翻译In conventional alphabeta T cells,the Tec family tyrosin
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