英语翻译Disseminated intravascular coagulation (DIC) remains acl

英语翻译
Disseminated intravascular coagulation (DIC) remains a
clinical diagnosis supported by laboratory data but with no
universally accepted diagnostic algorithm.The Japanese
Ministry of Health and Welfare (JMHW) proposed criteria
for the diagnosis of DIC 2 decades ago.1 The JMHW criteria
include semiquantitation of fibrin degradation products as 1
component of the scoring system.The complexity of the
algorithm and the current use of D-dimer assays limits the
applicability of this scoring system.The International Society
on Thrombosis and Haemostasis (ISTH) recently proposed a
DIC scoring system based on 4 laboratory parameters and the
presence of a predisposing condition.2 Elevation of a fibrinrelated
marker,such as D-dimer,represents a key element of
the ISTH algorithm,which also scores elevations in the
prothrombin time (PT) and decreases in the platelet count and
fibrinogen concentration.
Quantitative,rapid D-dimer assays with clinical performance
characteristics comparable to conventional enzymelinked
immunosorbent assays have become widely available
during the last several years.3,4 The immunoturbidimetric Ddimer
assays represent a relatively new class of automated Ddimer
tests that are based on photo-optical detection of
microlatex particle agglutination.5,6
Little is known about the performance of these sensitive
D-dimer assays in the context of patient evaluation for
suspected DIC.Therefore,we evaluated the analytic and
clinical performance of the STA LIATEST (Diagnostica
Stago,Parsippany,NJ) immunoturbidimetric D-dimer
assay in healthy people,in hospitalized patients not
suspected of having DIC,and in patients who have had Ddimer
assays ordered for suspected DIC.Because the
measurement of D-dimer has not been harmonized amongmarketed assays,cutoff values for scoring D-dimer elevations
in the ISTH algorithm need to be assay-specific.7 By
using receiver operating characteristic (ROC) curve
analysis,we identified a prospective cutoff that maximizes
sensitivity and specificity of the immunoturbidimetric Ddimer
assay.By using this cutoff,we compared the diagnostic
performance of the immunoturbidimetric D-dimer
assay with the ISTH scoring system.

弥漫性血管内凝血(DIC)仍然是一个
临床诊断实验室数据支持的但不带
普遍公认的诊断方法.日本
韩国健康与福脂部的(JMHW)提出的标准
(DIC)的诊断ago.1 JMHW二十年里的标准
纤维蛋白,包括semiquantitation降解产物为1
组成部分的得分系统.错综复杂的
算法与目前使用的d -二聚体检测限制了
该评分系统的适用性.国际社会
(ISTH在血栓形成和Haemostasis)最近提出了
DIC评分系统根据4实验室和参数
有缺陷condition.2面前的fibrinrelated标高
标记物,如d -二聚体,代表的一个主要因素
这ISTH不同海拔高度的算法,该算法也打进的
凝血酶原时间(PT)和减少血小板计数和
纤维蛋白原浓度.
定量、快速d -二聚体检测与临床表现
与常规enzymelinked特点
联免疫检测法已经成为广泛使用
在过去的几个years.3 immunoturbidimetric Ddimer,4
代表了一种相对较新的检测法的自动化Ddimer班
这类测试系统检测的基础上
microlatex粒子agglutination.5、6
很少有人了解这些敏感的性能
d -二聚体检测的语境中病人的评估
疑似DIC.因此,我们评估了解析和
临床表现LIATEST(Diagnostica STA的
Parsippany Stago immunoturbidimetric台北),d -二聚体
在健康的人,分析住院病人的不是
DIC的嫌疑人,而在患者都Ddimer
命令因涉嫌DIC检测法.因为
d -二聚体进行测量的amongmarketed尚未和谐的化验、截止值d -二聚体不同海拔高度的得分
在ISTH需要assay-specific.7算法
使用接受者操作特征(中华民国)曲线
分析,我们可以识别出未来的截止,最大限度